I listen to a lot of VGM, A LOT, before my place was broken into at the end of 2012 I had a 500GB External filled with VGM that I am still slowly refilling.
Super Metroid - Walking through a forest tripping on mushrooms while listening to this soundtrack is one of the best bad trips ever.
Street Fighter 2 - Ken's Theme. Fei Long's Theme, Cammy's.. Zangiefs.. Guile's.. I challenge you to not enjoy yourself while listening to ANYTHING from this game, It's impossible, then factor in the HDReMix edition, KABOOM goes your brain.
Chrono Trigger - Greatest Square Soundtrack Ever? Greatest Square Soundtrack Ever.
Donkey Kong Country 2 - The Standard Bearer for American VGM, 18 years later, Bramble Blast is still burned into my head, in about 9000 different arrangements.
Earthbound - Just go play the fucking game. 18 years since I bought that big gaudy box. Great Game, Great Story, Great Soundtrack.
Super Mario RPG - Top to Bottom the Best Mario Soundtrack, bar none.
Far Cry 3: Blood Dragon - Powerglove. Sloan's Assault.. nothing more needs to be said, literally the only thing I listened to for about a week, its the fucking tits.
Skyrim - I am a sucker for Orchestrated Music, for as unsophisticated as I am, I love nothing more than a brilliant Orchestra, nothing gets my heart racing faster than battle music in Skrim.
Legend of Zelda; A Link to the Past - All this mumbo jumbo about OoT is unfounded, ALttP is where its at, I will take Dark World over Gerudo Valley any day of the week, it's an unappreciated classic.
Tetris - If you don't find yourself humming this once a week then I can't be your friend.
Final Fantasy 7: Voices of the Lifestream - OCR's FF7 4 Disc Wonder, I'd list FF7 as its own, but god damn when Cosmo Canyon and Mark of the Traitor [Corel] are two of my favorite tracks and these rearrangements blow them the fuck out of the water "Lunatic Moon" and "Mark of the Beatsmith" respectively, I'll rank this ahead of the official OST.
Pokemon - Nothing to say here, it's just that amazing.
I could be here all day.