Yup.
I'm finding with the latest patch, the more 'out there' the system is, the better it works.
My current system is the 'DoppelDeuter'.
It shouldn't work, especially defensively, because there is no support for the full backs on the flanks, but the Raumdeuters play so far up the pitch, they pin back the opposition fullbacks long enough for the BWM to come across and close them down along with the fullback. Then attacking wise, the CF pulls a centre back away and the shadow striker and the RMD's can surge through the gap as Neumayer hits direct passes from deep. I've only played 10 or so games with it but the base framework is there for a well balanced system.
I also accidentally gave an outfield player the No. 1 jersey.