Cade, definitely follow TGC's advice on Peter David's X-Factor.
It is a great little corner of the Marvel Universe and while it does overlap with the major storylines (WWH, Civil War, Messiah Complex) from time to time, it never really lets them highjack the series' driving force: gritty character based drama. TGC covered a lot of what make the series so great. Personally, I think two of Peter David's greatest talents are, one, his ability to take B-list characters and getting you to care about them as if they were A-lister's, and two, having a tremendous imagination in terms of ways to use his character's abilities. I mean, Maddrox has one of the least defined powers of any Marvel character and for David really explores them.
I have fallen a little behind in the series but I am told that Darwin and Longshot have recently joined the team and that really excites me in that both of the aforementioned characters could flourish under his penning. Again both have fairly undefined powers and, especially in Darwin's case, aren't particularly established characters.
Edit: Also, I think that this would make a great show if Marvel ever wanted to venture into live action television again. Heck, maybe when Dollhouse is inevitably canceled they can even get Joss Whedon to write the project!
Edit:
Also, I can't believe some people don't like Daniel Way's current run on Deadpool! I love his characterization of Wade's madness and the art is the best Wilson has ever had on a solo book.